Visit Visit
Back to Home    
Visit Our ProgramsIntroduction to Chronic PainLow Back PainPost-Herpetic Neuralgia


Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial

January 1, 2004

This randomized controlled trial assessed the effectiveness of the use of prolotherapy injections and exercise in the treatment of chronic nonspecific low back pain. One hundred ten participants with chronic low-back pain averaging 14 years duration were randomized to have repeated prolotherapy injections (20% glucose/0.2% lignocaine) or normal saline injections into tender lumbo-pelvic ligaments and to perform either flexion/extension exercises or normal activity over 6 months. Pain intensity and disability scores were measured at 2.5, 4, 6, 12, and 24 months. Ligament injections, with either exercise or normal activity, resulted in significant and sustained reductions in pain and disability throughout the trial. This study showed that in chronic nonspecific low-back pain, significant and sustained reductions in pain and disability occur with ligament injections, regardless of the solution injected or the simultaneous use of exercises. Yelland MJ, Glasziou PP, Bogduk N, et al. University of Queensland, Brisbane, Australia. Spine, 29(1):9-16, 2004



Home | Contact Us | Privacy Policy | Disclaimer | Site Map
This website is generously supported by Medtronic, Inc.
©2004-2011 Continuum Health Partners, Inc.