One hundred patients with symptomatic knee osteoarthritis completed
a questionnaire to measure the effect of specific medication characteristics
(including administration, risks, benefits, and cost) on their choice
of medication, and the percentage of patients preferring NSAIDs, COX-2
inhibitors, glucosamine and/or chondroitin sulfate, opioid derivatives,
and capsaicin across different risks, benefits, and costs. Results showed
that adverse events dominate in the choice of medication over effectiveness.
Total capsaicin was preferred over other choices, with NSAIDS the least
chosen option. Fraenkel L, Bogardus ST Jr, Concato J, et al. Archives
of Internal Medicine. 28;164(12):1299-304, 2004.