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Antidepressants Confirmed as First-Line Treatment for Nerve Tissue Pain

New meta-analyses (reviews of studies) confirm that older-style antidepressants can help lessen neuropathic pain. Over 50 trials of 19 antidepressants were part of this review. Older tricyclic anti-depressants like amitriptyline proved especially helpful. More studies need to be done on the newer classes of antidepressants such as selective serontonin reuptake inhibitors (SSRIs) and selective Norepinephrine Reuptake Inhibitors (SNRIs) as well as on herbal medicines such as St. John’s Wort and dietary supplements such as L-tryptophan. Saarto T & Witten PJ. "Antidepressants for neuropathic pain." Cochrane Database of Systematic Reviews. 3, 2005.



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