NGX-4010, a high-concentration capsaicin skin patch, was tested in
patients with postherpetic neuralgia (PHN). Patients received either
NGX-4010 or a control patch in a 4-week, double-blind study which was
followed by up to 48 more weeks where patients could receive up to 3
additional treatments. The mean change in pain rating scores from baseline
during weeks 2-12 was -33.8% for the capsaicin patch and +4.9% for a
placebo patch. A similar decrease in pain scores from baseline was maintained
with subsequent capsaicin patch treatments, regardless of the number
of treatments received. No patients discontinued the study due to an
adverse event. NGX-4010 is a promising topical treatment for PHN patients,
which appears to be tolerable, generally safe, and effective.
Backonja MM, Malan TP, Vanhove GF, et al. University of Wisconsin-Madison.
NGX-4010, a high-concentration capsaicin patch, for the treatment of
postherpetic neuralgia: a randomized, double-blind, controlled study
with an open-label extension. Pain Medicine. 11(4):600-8, 2010